The ion channel genome is still being defined despite numerous publications on the subject. The ion channel transcriptome is even more difficult to assess. Using high-throughput computational tools, w…
Authors: Irene S Gabashvili, Bernd H A Sokolowski, Cynthia C Morton, Anne B S Giersch
Source: Journal of the Association for Research in Otolaryngology : JARO 2007 Sep
View Free Full TextThe crystal structures of the ribosome reveal remarkable complexity and provide a starting set of snapshots with which to understand the dynamics of translation. To augment the static crystallographic…
Authors: Irene S Gabashvili, Michelle Whirl-Carrillo, Michael Bada, D Rey Banatao, Russ B Altman
Source: RNA (New York, N.Y.) 2003 Nov
View Free Full TextThe publication of the crystal structures of the ribosome offers an opportunity to retrospectively evaluate the information content of hundreds of qualitative biochemical and biophysical studies of th…
Authors: Michelle Whirl-Carrillo, Irene S Gabashvili, Michael Bada, D Rey Banatao, Russ B Altman
Source: RNA (New York, N.Y.) 2002 Mar
View Free Full TextVariations in the inner ribosomal landscape determining the topology of nascent protein transport have been studied by three-dimensional cryo-electron microscopy of erythromycin-resistant Escherichia …
Authors: I S Gabashvili, S T Gregory, M Valle, R Grassucci, M Worbs, M C Wahl, A E Dahlberg, J Frank
Source: Molecular cell 2001 Jul
View Full TextThe ribosome undergoes pronounced periodic conformational changes during protein synthesis. Of particular importance are those occurring around the decoding site, the region of the 16 S rRNA interacti…
Authors: M S VanLoock, R K Agrawal, I S Gabashvili, L Qi, J Frank, S C Harvey
Source: Journal of molecular biology 2000 Dec 8
View Full TextUV-B radiation of 280 nm wavelength (UV280) and low intensity (2.0 W/m2) gives rise to an important oxygen evolution (OE) loss in photosystem II (PSII) particles isolated from the thylakoid membrane o…
Authors: J A Ségui, V Maire, I S Gabashvili, M Fragata
Source: Journal of photochemistry and photobiology. B, Biology 2000 Jun
View Full TextOver 73,000 projections of the E. coli ribosome bound with formyl-methionyl initiator tRNAf(Met) were used to obtain an 11.5 A cryo-electron microscopy map of the complex. This map allows identificati…
Authors: I S Gabashvili, R K Agrawal, C M Spahn, R A Grassucci, D I Svergun, J Frank, P Penczek
Source: Cell 2000 Mar 3
View Full TextDynamic changes in secondary structure of the 16S rRNA during the decoding of mRNA are visualized by three-dimensional cryo-electron microscopy of the 70S ribosome. Thermodynamically unstable base pai…
Authors: I S Gabashvili, R K Agrawal, R Grassucci, C L Squires, A E Dahlberg, J Frank
Source: The EMBO journal 1999 Nov 15
View Free Full TextA three-dimensional reconstruction of the 30 S subunit of the Escherichia coli ribosome was obtained at 23 A resolution. Because of the improved resolution, many more structural details are seen as co…
Authors: I S Gabashvili, R K Agrawal, R Grassucci, J Frank
Source: Journal of molecular biology 1999 Mar 12
View Full TextAuthors: A Khodjakov, I S Gabashvili, C L Rieder
Source: Cell motility and the cytoskeleton 1999
View Full TextCryo-electron microscopy of the ribosome in different binding states with mRNA and tRNA helps unravel the different steps of protein synthesis. Using over 29,000 projections of a ribosome complex in s…
Authors: A Malhotra, P Penczek, R K Agrawal, I S Gabashvili, R A Grassucci, R Jünemann, N Burkhardt, K H Nierhaus, J Frank
Source: Journal of molecular biology 1998 Jul 3
View Full TextFor viruses made of nucleic acid and protein, the structure of the protein outer shell has, in the past, been found to be uniquely determined by the viral genome. However, here, non-denaturing agarose…
Authors: I S Gabashvili, S A Khan, S J Hayes, P Serwer
Source: Journal of molecular biology 1997 Oct 31
View Full TextThe dynamics of dsDNA release process from a phage head has been analyzed theoretically. The process was considered as dsDNA reptation through the phage tail. The driving force is assumed to be the de…
Authors: I S Gabashvili, Grosberg AYu
Source: Journal of biomolecular structure & dynamics 1992 Apr
View Full TextStatistical model of dsDNA packaging to icosahedral bacteriophage capsid is presented. The model describes intraphage DNA as a globule, i.e. intramolecular liquid crystal. We analyse the free energy o…
Authors: I S Gabashvili, A Iu Grosberg, D V Kuznetsov, G M Mrevlishvili
Source: Biofizika 1991 Sep-Oct
View Full TextThe kinetics of reptation process of dsDNA leaving the phage head is analysed theoretically. It is assumed that the process is caused by DNA free energy decrease when it is leaving the head (DNA has t…
Authors: I S Gabashvili, A Iu Grosberg
Source: Biofizika 1991 Sep-Oct
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